Expression of MMP-2 and type-1 collagen was examined using immunohistochemistry staining. Methods: This was a true experimental study, using Sprague-Dawley rats and tomato juice (Solanum lycopersicum). This study aims to assess the effect of tomato juice on the expression of MMP-2 and type-1 collagen on the vaginal wall of the menopausal rat. Tomato fruit is an antioxidant, which acts as a binder and damper of free radicals that activate collagen damage. Collagen can be directly destroyed by reactive oxygen compounds or through the induction of MPPs. The accumulation of reactive oxygen compounds increases matrix metalloproteinase-2. Free radicals cause oxidative stress, which plays a role in the aging process. Juminten Saimin, Hendy Hendarto, Soetjipto Soetjiptoīackground: Aging is a multifactorial phenomenon that is characterized by a decrease in physiological functions that increases with age. The addition of sample size and analytic method studies should be considered for further research. The mean score of memory function in pyrethroid user was 2.5 and the average score of executive visuospatial function was 1.Ĭonclusion: Chronic exposure to the four types of pesticides provided a picture of neurocognitive function impairment, including memory, visuospatial and executive functions. This result did not show clinical significance. The samples of the study using carbamate pesticides had the same average score in both domains of neurocognitive function. The mean memory function score in the organochlorine user group was the highest compared to other groups of pesticide users while the average score of visuospatial function was 1. Organophosphate users experienced neurocognitive impairment in both memory domain (mean score of 1.5 what scoring was used?) and visuospatial executive functions (mean score of 1, what scoring system?). Most of the samples who experienced neurocognitive impairment used organophosphate pesticides (60%), followed by organochlorine (20%), carbamate (13.3%), and pyrethroid (6.7%). The median age of the study sample was 55 year-old. Results: A total of 60 samples, consisted of 36 samples (60%) were women and 24 samples (40%) were men were obtained. The study was conducted from 1 st January 2019 until 31 st January 2019 located in Banjar Tengah Kelod, Kerambitan sub-district, Tabanan district, Bali, Indonesia. Material and Methods: This study uses a descriptive cross-sectional design with total sampling methods. Purpose: This study aims to evaluate the characteristics of neurocognitive function in farmers exposed to chronic pesticides. Dewa Putu Gde Purwa Samatra, Ni Luh Putu Dirasandhi Semedi Putri
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